The thawing of ancient permafrost due to climate change may pose a new threat to humans, according to researchers who revived nearly two dozen viruses – including one frozen under a lake more than 48,500 years ago.

Scientists have long warned that the thawing of permafrost due to atmospheric warming will worsen climate change by freeing previously trapped greenhouse gases like methane. But its effect on dormant pathogens is less well understood.

“It is thus likely that ancient permafrost will release these unknown viruses upon thawing,” they wrote in an article posted to the preprint repository bioRxiv that hasn’t yet been peer-reviewed. “How long these viruses could remain infectious once exposed to outdoor conditions, and how likely they will be to encounter and infect a suitable host in the interval, is yet impossible to estimate.”

“But the risk is bound to increase in the context of global warming when permafrost thawing will keep accelerating, and more people will be populating the Arctic in the wake of industrial ventures,” they said.

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